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S.MirzaW.MurtazaM.NazirA.HanifI.AhmadM

Extensive efforts are in progress to understand the molecular mechanisms governing the role of ferroptosis in these conditions, and chelation therapy stands out as a potential approach to mitigate ferroptosis and its related implications in their development

To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH

Additionally, incorporating foods rich in sulfur, such as garlic and cruciferous vegetables, can support glutathione production, creating a synergistic effect